Indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.
About RYBELSUS®
How do you pronounce RYBELSUS®?
(reb-EL-sus) RYBELSUS®
What is RYBELSUS®?
RYBELSUS® is the world’s first and only oral GLP-1 RA.1 It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.1
How does RYBELSUS® work?
RYBELSUS® is a glucagon-like peptide-1 receptor agonist (GLP-1 RA) that mimics the body’s native GLP-1 hormone to respond to elevated levels of blood glucose. GLP-1 RAs reduce blood glucose by stimulating insulin secretion and lowering glucagon secretion, both in a glucose-dependent manner. The mechanism of blood glucose lowering also involves a minor delay in gastric emptying in the early postprandial phase.1
The RYBELSUS® molecule is stabilized against degradation by DPP-4, prolongs incretin activity, and is co-formulated with an absorption enhancer that enables once-daily oral administration.1,a
aSNAC: Sodium-N-[8-(2-hydroxybenzoyl)amino]caprylate: a small fatty-acid derivative.
Will RYBELSUS® help my patients lose weight?
RYBELSUS® is not indicated for weight loss.
While the primary endpoint in the majority of RYBELSUS® clinical trials was mean change in A1C, mean change in body weight was generally evaluated as a confirmatory secondary endpoint. Review some of these studies for additional information and see the Prescribing Information.
What are the side effects of RYBELSUS®?
The most frequently reported adverse reactions, excluding hypoglycemia, in clinical trials that occurred in at least 5% of patients treated with RYBELSUS® were GI-related, including nausea, abdominal pain, diarrhea, decreased appetite, vomiting, and constipation. Nausea, vomiting, and/or diarrhea occurred mostly during dose escalation. 4% and 8% of patients discontinued RYBELSUS® 7 mg and 14 mg, respectively, due to GI adverse reactions, compared to 1% of patients receiving placebo.1
Taking RYBELSUS®
How do you take RYBELSUS®?
For RYBELSUS® to work as intended, proper administration is important.1 See full dosing instructions.
How often is RYBELSUS® taken?
RYBELSUS® should be taken orally once daily, the same way every day. Patients should understand and follow all of the administration instructions for it to work as intended. Read about the proper way to take RYBELSUS®.
Does RYBELSUS® need to be refrigerated?
Unlike other GLP-1 RA therapies, RYBELSUS® should not be refrigerated. It should be stored at room temperature 68°F—77°F (20°C—25°C) in a dry place away from moisture.1 You should discuss all the important storage information with your patients for RYBELSUS® to work as intended. See key storage information.
How long is RYBELSUS® active?
RYBELSUS® is a once-daily oral tablet. Following administration, the maximum concentration is reached after 1 hour, and the half-life is approximately 1 week. Steady-state exposure is achieved following 4 to 5 weeks of administration.
How is RYBELSUS® packaged and supplied?
RYBELSUS® tablets are available as a 30-day supply of 3 x 10 count blister packs in 3-mg (green carton), 7-mg (red carton), or 14-mg (blue carton) dosages. Read more about dosing and prescribing RYBELSUS® and find more on supplying and storage in Section 16 of the Prescribing Information.
Patient support
Where can I send my patients for savings information?
Eligible patients will pay as little as $10 on their 30-day prescription of RYBELSUS®.b They can take advantage of this offer by texting READY to 21848 or by downloading a savings card at SaveOnR.com.c
bFor commercially insured patients only. Additional eligibility and restrictions apply.
cMessage and data rates may apply. Check with mobile service provider. See Terms and Conditions of Use at RYBELSUS.com.
Are there other support programs available?
Signing up for savings automatically enrolls your patients in patient support. If they sign up for savings via text, they will receive text message support. If they sign up for savings online, they will receive email support. At any time, patients can call 1-833-ASK-A-CDE (1-833-275-2233) for one-on-one support from a Certified Diabetes Educator (CDE).
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